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Differential Activation of Influenza A Virus Endonuclease Activity Is Dependent on Multiple Sequence Differences between the Virion RNA and cRNA Promoters

Influenza virus endonuclease activity was studied in vitro with model virion RNA (vRNA) and cRNA molecules. We show that endonuclease activity can be partially rescued by transplanting vRNA-like promoter features into the model cRNA promoter. This study defines three distinctive features within the...

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Autori principali: Leahy, Michael B., Zecchin, Giuseppe, Brownlee, George G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC135883/
https://ncbi.nlm.nih.gov/pubmed/11799200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.2019-2023.2002
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