Kaposi's Sarcoma-Associated Herpesvirus-Encoded G Protein-Coupled Receptor ORF74 Constitutively Activates p44/p42 MAPK and Akt via G(i) and Phospholipase C-Dependent Signaling Pathways

The G protein-coupled receptor encoded by Kaposi's sarcoma-associated herpesvirus, also referred to as ORF74, has been shown to stimulate oncogenic and angiogenic signaling pathways in a constitutively active manner. The biochemical routes linking ORF74 to these signaling pathways are poorly de...

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Autori principali: Smit, Martine J., Verzijl, Dennis, Casarosa, Paola, Navis, Marjon, Timmerman, Henk, Leurs, Rob
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC135879/
https://ncbi.nlm.nih.gov/pubmed/11799169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1744-1752.2002
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