Kaposi's Sarcoma-Like Tumors in a Human Herpesvirus 8 ORF74 Transgenic Mouse

The product of human herpesvirus 8 (HHV-8) open reading frame 74 (ORF74) is related structurally and functionally to cellular chemokine receptors. ORF74 activates several cellular signaling pathways in the absence of added ligands, and NIH 3T3 cells expressing ORF74 are tumorigenic in nude mice. We...

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Detalhes bibliográficos
Main Authors: Guo, Hong-Guang, Sadowska, Mariola, Reid, William, Tschachler, Erwin, Hayward, Gary, Reitz, Marvin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC141078/
https://ncbi.nlm.nih.gov/pubmed/12552002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.4.2631-2639.2003
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