Kaposi's Sarcoma-Like Tumors in a Human Herpesvirus 8 ORF74 Transgenic Mouse

The product of human herpesvirus 8 (HHV-8) open reading frame 74 (ORF74) is related structurally and functionally to cellular chemokine receptors. ORF74 activates several cellular signaling pathways in the absence of added ligands, and NIH 3T3 cells expressing ORF74 are tumorigenic in nude mice. We...

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Pubblicato in:	J Virol
Autori principali:	Guo, Hong-Guang, Sadowska, Mariola, Reid, William, Tschachler, Erwin, Hayward, Gary, Reitz, Marvin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141078/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12552002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.4.2631-2639.2003
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