Activation of p38 and ERK Signaling during Adenovirus Vector Cell Entry Lead to Expression of the C-X-C Chemokine IP-10

The use of adenovirus vectors for human gene therapy is limited by potent inflammatory responses that result in significant morbidity. In kidney-derived epithelial cells (REC), activation of extracellular signal-regulated kinase 1/2 (ERK) and p38 kinase (p38) pathways occurred within 20 min of trans...

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Main Authors: Tibbles, Lee Anne, Spurrell, Jason C. L., Bowen, Gloria P., Liu, Qiang, Lam, Mindy, Zaiss, Anne K., Robbins, Stephen M., Hollenberg, Morley D., Wickham, Thomas J., Muruve, Daniel A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2002
主題:
Gene Therapy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC135878/
https://ncbi.nlm.nih.gov/pubmed/11799150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.4.1559-1568.2002
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