A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels

After ocular herpes simplex virus type 1 (HSV-1) infection, the virus travels up axons and establishes a lifelong latent infection in neurons of the trigeminal ganglia. LAT (latency-associated transcript), the only known viral gene abundantly transcribed during HSV-1 neuronal latency, is required fo...

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Detalhes bibliográficos
Main Authors: Perng, Guey-Chuen, Maguen, Barak, Jin, Ling, Mott, Kevin R., Osorio, Nelson, Slanina, Susan M., Yukht, Ada, Ghiasi, Homayon, Nesburn, Anthony B., Inman, Melissa, Henderson, Gail, Jones, Clinton, Wechsler, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135864/
https://ncbi.nlm.nih.gov/pubmed/11773398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.3.1224-1235.2002
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