Three Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutants with Distinct and Asymmetric Effects on Virulence in Mice Compared with Rabbits

Herpes simplex virus type 1 latency-associated transcript (LAT)-null mutants have decreased reactivation but normal virulence in rabbits and mice. We report here on dLAT1.5, a mutant with LAT nucleotides 76 to 1667 deleted. Following ocular infection of rabbits, dLAT1.5 reactivated at a lower rate t...

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Detalhes bibliográficos
Main Authors: Perng, Guey-Chuen, Esmaili, Daniel, Slanina, Susan M., Yukht, Ada, Ghiasi, Homayon, Osorio, Nelson, Mott, Kevin R., Maguen, Barak, Jin, Ling, Nesburn, Anthony B., Wechsler, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114470/
https://ncbi.nlm.nih.gov/pubmed/11533165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.19.9018-9028.2001
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