Complement Component C1q Enhances the Biological Activity of Influenza Virus Hemagglutinin-Specific Antibodies Depending on Their Fine Antigen Specificity and Heavy-Chain Isotype

We have previously observed that selected influenza virus hemagglutinin (HA)-specific monoclonal antibodies (MAbs) with poor virus-neutralizing (VN) activity in vitro exhibited greatly enhanced VN activity in vivo after administration to SCID mice. The same Abs displayed improved VN activity also wh...

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Detalhes bibliográficos
Main Authors: Feng, Jing Qi, Mozdzanowska, Krystyna, Gerhard, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135831/
https://ncbi.nlm.nih.gov/pubmed/11773411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.3.1369-1378.2002
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