Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific N-Glycosylation Profiles

Antibodies are critical glycoproteins that bridge the innate and adaptive immune systems to provide protection against infection. The isotype/subclass of the antibody, the co-translational N-glycosylation on the CH2 domain, and the remodeling of the N-linked glycans during passage through the ER and...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Chandler, Kevin Brown, Mehta, Nickita, Leon, Deborah R., Suscovich, Todd J., Alter, Galit, Costello, Catherine E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442369/
https://ncbi.nlm.nih.gov/pubmed/30659065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.001185
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