Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR

Defects of mitochondrial DNA (mtDNA) are an important cause of disease and play a role in the ageing process. There are multiple copies of the mitochondrial genome in a single cell. In many patients with acquired or inherited mtDNA mutations, there exists a mixture of mutated and wild type genomes (...

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Εκδόθηκε σε:	Nucleic Acids Res
Κύριοι συγγραφείς:	He, Langping, Chinnery, Patrick F., Durham, Steve E., Blakely, Emma L., Wardell, Theresa M., Borthwick, Gillian M., Taylor, Robert W., Turnbull, Douglass M.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Oxford University Press 2002
Θέματα:	NAR Methods Online
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135769/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12136116/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gnf067
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