Mutation analysis of the entire mitochondrial genome using denaturing high performance liquid chromatography

In patients with mitochondrial disease a continuously increasing number of mitochondrial DNA (mtDNA) mutations and polymorphisms have been identified. Most pathogenic mtDNA mutations are heteroplasmic, resulting in heteroduplexes after PCR amplification of mtDNA. To detect these heteroduplexes, we u...

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Autori principali: van den Bosch, Bianca J. C., de Coo, René F. M., Scholte, Hans R., Nijland, Jeroen G., van den Bogaard, Ruud, de Visser, Marianne, de Die-Smulders, Christine E. M., Smeets, Hubert J. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2000
Soggetti:
NAR Methods Online
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC110805/
https://ncbi.nlm.nih.gov/pubmed/11024191
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