Mutation analysis of the entire mitochondrial genome using denaturing high performance liquid chromatography

In patients with mitochondrial disease a continuously increasing number of mitochondrial DNA (mtDNA) mutations and polymorphisms have been identified. Most pathogenic mtDNA mutations are heteroplasmic, resulting in heteroduplexes after PCR amplification of mtDNA. To detect these heteroduplexes, we u...

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書誌詳細

出版年:	Nucleic Acids Res
主要な著者:	van den Bosch, Bianca J. C., de Coo, René F. M., Scholte, Hans R., Nijland, Jeroen G., van den Bogaard, Ruud, de Visser, Marianne, de Die-Smulders, Christine E. M., Smeets, Hubert J. M.
フォーマット:	Artigo
言語:	Inglês
出版事項:	Oxford University Press 2000
主題:	NAR Methods Online
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110805/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11024191/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.20.e89
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