Identification of a Novel Mitogen-Activated Protein Kinase Kinase Activation Domain Recognized by the Inhibitor PD 184352

Utilizing a genetic screen in the yeast Saccharomyces cerevisiae, we identified a novel autoactivation region in mammalian MEK1 that is involved in binding the specific MEK inhibitor, PD 184352. The genetic screen is possible due to the homology between components of the yeast pheromone response pat...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Delaney, Amy M., Printen, John A., Chen, Huifen, Fauman, Eric B., Dudley, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135683/
https://ncbi.nlm.nih.gov/pubmed/12370306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7593-7602.2002
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados