A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal-regulated kinases, or ERKs). We have identified a synthetic inhibitor of the MAPK pathway. PD 098059 [2-(2'-am...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Dudley, D T, Pang, L, Decker, S J, Bridges, A J, Saltiel, A R
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644477/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7686
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