Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

Hypoxia profoundly influences tumor development and response to therapy. While progress has been made in identifying individual gene products whose synthesis is altered under hypoxia, little is known about the mechanism by which hypoxia induces a global downregulation of protein synthesis. A critica...

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Bibliographische Detailangaben
Hauptverfasser: Koumenis, Constantinos, Naczki, Christine, Koritzinsky, Marianne, Rastani, Sally, Diehl, Alan, Sonenberg, Nahum, Koromilas, Antonis, Wouters, Bradly G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC135664/
https://ncbi.nlm.nih.gov/pubmed/12370288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7405-7416.2002
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