Drosophila PDZ-GEF, a Guanine Nucleotide Exchange Factor for Rap1 GTPase, Reveals a Novel Upstream Regulatory Mechanism in the Mitogen-Activated Protein Kinase Signaling Pathway

PDZ-GEF is a novel guanine nucleotide exchange factor for Rap1 GTPase. Here we isolated Drosophila melanogaster PDZ-GEF (dPDZ-GEF), which contains the all-conserved domains of mammalian and nematode PDZ-GEF including cyclic nucleotide monophosphate-binding, Ras exchange motif, PDZ, RA, and GEF domai...

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Detalhes bibliográficos
Main Authors: Lee, Jun Hee, Cho, Kyoung Sang, Lee, Jihyun, Kim, Dohoon, Lee, Sung-Bae, Yoo, Jungsik, Cha, Guang-Ho, Chung, Jongkyeong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135652/
https://ncbi.nlm.nih.gov/pubmed/12370312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.21.7658-7666.2002
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