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Molecular basis of RNA recognition by the human alternative splicing factor Fox-1
The Fox-1 protein regulates alternative splicing of tissue-specific exons by binding to GCAUG elements. Here, we report the solution structure of the Fox-1 RNA binding domain (RBD) in complex with UGCAUGU. The last three nucleotides, UGU, are recognized in a canonical way by the four-stranded β-shee...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356361/ https://ncbi.nlm.nih.gov/pubmed/16362037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600918 |
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