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Molecular basis of RNA recognition by the human alternative splicing factor Fox-1

The Fox-1 protein regulates alternative splicing of tissue-specific exons by binding to GCAUG elements. Here, we report the solution structure of the Fox-1 RNA binding domain (RBD) in complex with UGCAUGU. The last three nucleotides, UGU, are recognized in a canonical way by the four-stranded β-shee...

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Bibliografiske detaljer
Main Authors: Auweter, Sigrid D, Fasan, Rudi, Reymond, Luc, Underwood, Jason G, Black, Douglas L, Pitsch, Stefan, Allain, Frédéric H-T
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356361/
https://ncbi.nlm.nih.gov/pubmed/16362037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600918
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