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SIKE is an IKKɛ/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways
Viral infection or TLR3 engagement causes activation of the transcription factors IRF-3 and NF-κB, which collaborate to induce transcription of type I IFN genes. IKKɛ and TBK1 are two IKK-related kinases critically involved in virus- and TLR3-triggered activation of IRF-3. We identified a protein te...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356304/ https://ncbi.nlm.nih.gov/pubmed/16281057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600863 |
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