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The amyloid-β precursor protein: integrating structure with biological function
Proteolytic processing of the amyloid-β precursor protein (APP) generates the Aβ amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional signif...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356301/ https://ncbi.nlm.nih.gov/pubmed/16252002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600860 |
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