Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation

Pdx1 (IPF-1 in humans, which is altered in MODY-4) is essential for pancreas development and mature β-cell function. Pdx1 is expressed dynamically within the developing foregut, but how its expression characteristics are linked to the various steps of organ specification, differentiation, and functi...

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Autors principals: Fujitani, Yoshio, Fujitani, Shuko, Boyer, Daniel F., Gannon, Maureen, Kawaguchi, Yoshiya, Ray, Michael, Shiota, Masakazu, Stein, Roland W., Magnuson, Mark A., Wright, Christopher V.E.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2006
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356115/
https://ncbi.nlm.nih.gov/pubmed/16418487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1360106
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