Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain

Two of the four human FGF8 splice isoforms, FGF8a and FGF8b, are expressed in the mid-hindbrain region during development. Although the only difference between these isoforms is the presence of an additional 11 amino acids at the N terminus of FGF8b, these isoforms possess remarkably different abili...

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Bibliografiska uppgifter
Huvudupphovsmän: Olsen, Shaun K., Li, James Y.H., Bromleigh, Carrie, Eliseenkova, Anna V., Ibrahimi, Omar A., Lao, Zhimin, Zhang, Fuming, Linhardt, Robert J., Joyner, Alexandra L., Mohammadi, Moosa
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2006
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356110/
https://ncbi.nlm.nih.gov/pubmed/16384934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1365406
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