The Endothelial Receptor Tyrosine Kinase Tie1 Activates Phosphatidylinositol 3-Kinase and Akt To Inhibit Apoptosis

Tie1 is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. Genetic studies suggest that Tie1 promotes endothelial cell survival, but other studies have suggested that the Tie1 kinase has little...

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Bibliographic Details
Main Authors: Kontos, Christopher D., Cha, Eugene H., York, John D., Peters, Kevin G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC135589/
https://ncbi.nlm.nih.gov/pubmed/11865050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.6.1704-1713.2002
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