The MexR Repressor of the mexAB-oprM Multidrug Efflux Operon in Pseudomonas aeruginosa: Characterization of Mutations Compromising Activity

Mutations in mexR yield a multidrug resistance phenotype in nalB mutants of Pseudomonas aeruginosa as a result of derepression of the mexAB-oprM multidrug efflux operon. MexR produced by several nalB strains carried single amino acid changes that compromised MexR stability or its ability to dimerize...

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Autores principales: Adewoye, Lateef, Sutherland, Ainsley, Srikumar, Ramakrishnan, Poole, Keith
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC135222/
https://ncbi.nlm.nih.gov/pubmed/12107151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.15.4308-4312.2002
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