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A novel and evolutionarily conserved PtdIns(3,4,5)P(3)-binding domain is necessary for DOCK180 signaling
Directional cell movement is initiated by the generation of a PtdIns(3,4,5)P(3) gradient at the cell membrane, which is followed by Rac GTPase-mediated actin rearrangement. The evolutionarily conserved DOCK180 protein has an indispensable role in cell migration by functioning as an atypical guanine...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1352170/ https://ncbi.nlm.nih.gov/pubmed/16025104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1280 |
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