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Activation of Antibiotic Biosynthesis by Specified Mutations in the rpoB Gene (Encoding the RNA Polymerase β Subunit) of Streptomyces lividans

We found that the biosynthesis of actinorhodin (Act), undecylprodigiosin (Red), and calcium-dependent antibiotic (CDA) are dramatically activated by introducing certain mutations into the rpoB gene that confer resistance to rifampin to Streptomyces lividans 66, which produces less or no antibiotics...

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Autors principals: Hu, Haifeng, Zhang, Qin, Ochi, Kozo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC135172/
https://ncbi.nlm.nih.gov/pubmed/12081971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.14.3984-3991.2002
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