Activation of Antibiotic Biosynthesis by Specified Mutations in the rpoB Gene (Encoding the RNA Polymerase β Subunit) of Streptomyces lividans

We found that the biosynthesis of actinorhodin (Act), undecylprodigiosin (Red), and calcium-dependent antibiotic (CDA) are dramatically activated by introducing certain mutations into the rpoB gene that confer resistance to rifampin to Streptomyces lividans 66, which produces less or no antibiotics...

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Pubblicato in:	J Bacteriol
Autori principali:	Hu, Haifeng, Zhang, Qin, Ochi, Kozo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Genetics and Molecular Biology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135172/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12081971/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.184.14.3984-3991.2002
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