Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice

Null mutations of the proopiomelanocortin gene (Pomc(–/–)) cause obesity in humans and rodents, but the contributions of central versus pituitary POMC deficiency are not fully established. To elucidate these roles, we introduced a POMC transgene (Tg) that selectively restored peripheral melanocortin...

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Detaylı Bibliyografya
Asıl Yazarlar: Smart, James L., Tolle, Virginie, Low, Malcolm J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2006
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1350998/
https://ncbi.nlm.nih.gov/pubmed/16440060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25243
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