Local Simvastatin Effects on Mandibular Bone Growth and Inflammation

Background: Simvastatin has been shown to increase bone growth when applied topically to murine bone; however, it caused considerable soft tissue inflammation at high doses (2.2 mg), making future clinical use problematic. This study evaluated the effect of lower simvastatin doses and cyclooxygenase...

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Detalhes bibliográficos
Main Authors: Stein, David, Lee, Yeonju, Schmid, Marian J., Killpack, Byron, Genrich, Mikala A., Narayana, Nagamani, Marx, David B., Cullen, Diane M., Reinhardt, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1350642/
https://ncbi.nlm.nih.gov/pubmed/16274305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1902/jop.2005.76.11.1861
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