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Cyclooxygenase-2 Inhibitor Reduces Simvastatin-Induced Bone Morphogenetic Protein-2 and Bone Formation In Vivo
OBJECTIVES: Simvastatin, a cholesterol-lowering drug, also stimulates oral bone growth when applied topically, without systemic side effects. However, the mechanisms involved in vivo are not known. We hypothesized that bone morphogenetic protein-2 (BMP-2), nitric oxide synthase (NOS) and cyclooxygen...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014720/ https://ncbi.nlm.nih.gov/pubmed/17451547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0765.2006.00943.x |
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