Cyclooxygenase-2 Inhibitor Reduces Simvastatin-Induced Bone Morphogenetic Protein-2 and Bone Formation In Vivo

OBJECTIVES: Simvastatin, a cholesterol-lowering drug, also stimulates oral bone growth when applied topically, without systemic side effects. However, the mechanisms involved in vivo are not known. We hypothesized that bone morphogenetic protein-2 (BMP-2), nitric oxide synthase (NOS) and cyclooxygen...

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Autors principals: Bradley, J. D., Cleverly, D. G., Burns, A. M., Helm, N. B., Schmid, M. J., Marx, D. B., Cullen, D. M., Reinhardt, R. A.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014720/
https://ncbi.nlm.nih.gov/pubmed/17451547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0765.2006.00943.x
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