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Papillomavirus E1 Protein Binds to and Stimulates Human Topoisomerase I

The papillomavirus (PV) E1 helicase plays a direct role in recruiting cellular DNA replication factors, such as replication protein A or polymerase α-primase, to replicate PV genomes. Here, E1 is shown to bind to human topoisomerase I and stimulate its relaxation activity up to sevenfold. The intera...

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Autors principals: Clower, Randolph V., Fisk, John C., Melendy, Thomas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346965/
https://ncbi.nlm.nih.gov/pubmed/16415033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1584-1587.2006
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