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Fine Structure and Activity of Discrete RAG-HMG Complexes on V(D)J Recombination Signals

Two lymphoid cell-specific proteins, RAG-1 and RAG-2, initiate V(D)J recombination by introducing DNA breaks at recombination signal sequences (RSSs). Although the RAG proteins themselves bind and cleave DNA substrates containing either a 12-RSS or a 23-RSS, DNA-bending proteins HMG-1 and HMG-2 are...

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Bibliografiske detaljer
Hovedforfatter: Swanson, Patrick C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC134695/
https://ncbi.nlm.nih.gov/pubmed/11839801
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