Redirecting Coronavirus to a Nonnative Receptor through a Virus-Encoded Targeting Adapter

Murine hepatitis coronavirus (MHV)-A59 infection depends on the interaction of its spike (S) protein with the cellular receptor mCEACAM1a present on murine cells. Human cells lack this receptor and are therefore not susceptible to MHV. Specific alleviation of the tropism barrier by redirecting MHV t...

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Main Authors: Verheije, M. H., Würdinger, T., van Beusechem, V. W., de Haan, C. A. M., Gerritsen, W. R., Rottier, P. J. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346946/
https://ncbi.nlm.nih.gov/pubmed/16415002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1250-1260.2006
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