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Role of Helix P of the Human Cytomegalovirus DNA Polymerase in Resistance and Hypersusceptibility to the Antiviral Drug Foscarnet

Mutations in the human cytomegalovirus DNA polymerase (UL54) can not only decrease but also increase susceptibility to the pyrophosphate (PP(i)) analogue foscarnet. The proximity of L802M, which confers resistance, and K805Q, which confers hypersusceptibility, suggests a possible unifying mechanism...

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Bibliografiske detaljer
Main Authors: Tchesnokov, Egor P., Gilbert, Christian, Boivin, Guy, Götte, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1346920/
https://ncbi.nlm.nih.gov/pubmed/16415021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.3.1440-1450.2006
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