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Engineering of a Chimeric RB69 DNA Polymerase Sensitive to Drugs Targeting the Cytomegalovirus Enzyme

Detailed structural and biochemical studies with the human cytomegalovirus (HCMV UL54) DNA polymerase are hampered by difficulties to obtain this enzyme in large quantities. The crystal structure of the related RB69 DNA polymerase (gp43) is often used as a model system to explain mechanisms of inhib...

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Main Authors: Tchesnokov, Egor P., Obikhod, Aleksandr, Schinazi, Raymond F., Götte, Matthias
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785332/
https://ncbi.nlm.nih.gov/pubmed/19622750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.012500
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