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Characterization of SPAK and OSR1, Regulatory Kinases of the Na-K-2Cl Cotransporter
Our recent studies demonstrate that SPAK (Ste20p-related Proline Alanine-rich Kinase), in combination with WNK4 [With No lysine (K) kinase], phosphorylates and stimulates the Na-K-2Cl cotransporter (NKCC1), whereas catalytically inactive SPAK (K104R) fails to activate the cotransporter. The catalyti...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1346913/ https://ncbi.nlm.nih.gov/pubmed/16382158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.2.689-698.2006 |
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