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Biochemistry and Comparative Genomics of SxxK Superfamily Acyltransferases Offer a Clue to the Mycobacterial Paradox: Presence of Penicillin-Susceptible Target Proteins versus Lack of Efficiency of Penicillin as Therapeutic Agent
The bacterial acyltransferases of the SxxK superfamily vary enormously in sequence and function, with conservation of particular amino acid groups and all-α and α/β folds. They occur as independent entities (free-standing polypeptides) and as modules linked to other polypeptides (protein fusions). T...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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American Society for Microbiology
2002
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC134655/ https://ncbi.nlm.nih.gov/pubmed/12456788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MMBR.66.4.702-738.2002 |
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