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Proteolytic Cleavage and Phosphorylation of a Tumor-associated ErbB4 Isoform Promote Ligand-independent Survival and Cancer Cell Growth

The ErbB1 and ErbB2 receptors are oncogenes with therapeutic significance in human cancer, whereas the transforming potential of the related ErbB4 receptor has remained controversial. Here, we have addressed whether four alternatively spliced ErbB4 isoforms differ in regulating cellular responses re...

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Autores principales: Määttä, Jorma A., Sundvall, Maria, Junttila, Teemu T., Peri, Liisa, Laine, V. Jukka O., Isola, Jorma, Egeblad, Mikala, Elenius, Klaus
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1345647/
https://ncbi.nlm.nih.gov/pubmed/16251361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-05-0402
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