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Design and cloning strategies for constructing shRNA expression vectors

BACKGROUND: Short hairpin RNA (shRNA) encoded within an expression vector has proven an effective means of harnessing the RNA interference (RNAi) pathway in mammalian cells. A survey of the literature revealed that shRNA vector construction can be hindered by high mutation rates and the ensuing sequ...

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Hlavní autoři: McIntyre, Glen J, Fanning, Gregory C
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1343552/
https://ncbi.nlm.nih.gov/pubmed/16396676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-6-1
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