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Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.
To explore the basis of apparent conformational heterogeneity of cytochrome P450 3A4 (CYP3A4) the kinetics of dithionite-dependent reduction was studied in solution, in proteoliposomes and in Nanodiscs. In CYP3A4 oligomers in solution the kinetics obeys a three-exponential equation with similar ampl...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1343486/ https://ncbi.nlm.nih.gov/pubmed/16229479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0509346 |
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