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Regulated costimulation in the thymus is critical for T cell development: Dysregulated CD28 costimulation can bypass the pre-TCR checkpoint
Expression of CD28 is highly regulated during thymic development, with CD28 levels extremely low on immature thymocytes but increasing dramatically as CD4(−)CD8(−) cells initiate expression of TCRβ. B7-1 and B7-2, the ligands for CD28, have a restricted distribution in the thymic cortex where immatu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1343453/ https://ncbi.nlm.nih.gov/pubmed/16177059 |
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