Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus
The human Werner syndrome protein, WRN, is a member of the RecQ helicase family and contains 3′→5′ helicase and 3′→5′ exonuclease activities. Recently, we showed that the exonuclease activity of WRN is greatly stimulated by the human Ku heterodimer protein. We have now mapped this interaction physic...
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| Publicat a: | Nucleic Acids Res |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12177300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf482 |
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