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Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus

The human Werner syndrome protein, WRN, is a member of the RecQ helicase family and contains 3′→5′ helicase and 3′→5′ exonuclease activities. Recently, we showed that the exonuclease activity of WRN is greatly stimulated by the human Ku heterodimer protein. We have now mapped this interaction physic...

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Bibliografski detalji
Glavni autori: Karmakar, Parimal, Snowden, Carey M., Ramsden, Dale A., Bohr, Vilhelm A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC134248/
https://ncbi.nlm.nih.gov/pubmed/12177300
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