Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus

The human Werner syndrome protein, WRN, is a member of the RecQ helicase family and contains 3′→5′ helicase and 3′→5′ exonuclease activities. Recently, we showed that the exonuclease activity of WRN is greatly stimulated by the human Ku heterodimer protein. We have now mapped this interaction physic...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Karmakar, Parimal, Snowden, Carey M., Ramsden, Dale A., Bohr, Vilhelm A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12177300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf482
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