Strong Natural Pausing by RNA Polymerase II within 10 Bases of Transcription Start May Result in Repeated Slippage and Reextension of the Nascent RNA

We find that immediately following transcript initiation, RNA polymerase II pauses at several locations even in the presence of relatively high (200 μM) levels of nucleoside triphosphates. Strong pauses with half-lives of >30 s were observed at +7, +18/19, and about +25 on the template used in these...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Pal, Mahadeb, Luse, Donal S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2002
Schlagworte:	Transcriptional Regulation
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739720/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.1.30-40.2002
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!