Strong Natural Pausing by RNA Polymerase II within 10 Bases of Transcription Start May Result in Repeated Slippage and Reextension of the Nascent RNA

We find that immediately following transcript initiation, RNA polymerase II pauses at several locations even in the presence of relatively high (200 μM) levels of nucleoside triphosphates. Strong pauses with half-lives of >30 s were observed at +7, +18/19, and about +25 on the template used in these...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Pal, Mahadeb, Luse, Donal S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Transcriptional Regulation
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC134219/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739720/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.1.30-40.2002
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