Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 Phosphorylation

Translation of terminal oligopyrimidine tract (TOP) mRNAs, which encode multiple components of the protein synthesis machinery, is known to be controlled by mitogenic stimuli. We now show that the ability of cells to progress through the cell cycle is not a prerequisite for this mode of regulation....

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Detalhes bibliográficos
Main Authors: Stolovich, Miri, Tang, Hua, Hornstein, Eran, Levy, Galit, Cohen, Ruth, Bae, Sun Sik, Birnbaum, Morris J., Meyuhas, Oded
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134064/
https://ncbi.nlm.nih.gov/pubmed/12417714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.23.8101-8113.2002
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