High Bone Resorption in Adult Aging Transgenic Mice Overexpressing Cbfa1/Runx2 in Cells of the Osteoblastic Lineage

The runt family transcription factor core-binding factor α1 (Cbfa1) is essential for bone formation during development. Surprisingly, transgenic mice overexpressing Cbfa1 under the control of the 2.3-kb collagen type I promoter developed severe osteopenia that increased progressively with age and pr...

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Bibliographische Detailangaben
Hauptverfasser: Geoffroy, Valérie, Kneissel, Michaela, Fournier, Brigitte, Boyde, Alan, Matthias, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC134019/
https://ncbi.nlm.nih.gov/pubmed/12167715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.17.6222-6233.2002
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