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Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes

The p53 tumor suppressor regulates the cellular response to genetic damage through its function as a sequence-specific transcription factor. Among the most well-characterized transcriptional targets of p53 is the mdm2 oncogene. Activation of mdm2 is critical in the p53 pathway because the mdm2 prote...

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Udgivet i:Mol Cell Biol
Principais autores: Ard, Penny G., Chatterjee, Chandrima, Kunjibettu, Sudeesha, Adside, Leon R., Gralinski, Lisa E., McMahon, Steven B.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133988/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12138177/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.16.5650-5661.2002
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