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Guanidine Hydrochloride Inhibits the Generation of Prion “Seeds” but Not Prion Protein Aggregation in Yeast

[PSI(+)] strains of the yeast Saccharomyces cerevisiae replicate and transmit the prion form of the Sup35p protein but can be permanently cured of this property when grown in millimolar concentrations of guanidine hydrochloride (GdnHCl). GdnHCl treatment leads to the inhibition of the replication of...

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Autores principales: Ness, Frédérique, Ferreira, Paulo, Cox, Brian S., Tuite, Mick F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC133959/
https://ncbi.nlm.nih.gov/pubmed/12101251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.15.5593-5605.2002
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