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Cell division is essential for elimination of the yeast [PSI(+)] prion by guanidine hydrochloride

Guanidine hydrochloride (Gdn·HCl) blocks the propagation of yeast prions by inhibiting Hsp104, a molecular chaperone that is absolutely required for yeast prion propagation. We had previously proposed that ongoing cell division is required for Gdn·HCl-induced loss of the [PSI(+)] prion. Subsequently...

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Bibliografiske detaljer
Main Authors: Byrne, Lee J., Cox, Brian S., Cole, Diana J., Ridout, Martin S., Morgan, Byron J. T., Tuite, Mick F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913874/
https://ncbi.nlm.nih.gov/pubmed/17606924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701392104
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