PIN1 Is an E2F Target Gene Essential for Neu/Ras-Induced Transformation of Mammary Epithelial Cells

Oncogenes Neu/HER2/ErbB2 and Ras can induce mammary tumorigenesis via upregulation of cyclin D1. One major regulatory mechanism in these oncogenic signaling pathways is phosphorylation of serines or threonines preceding proline (pSer/Thr-Pro). Interestingly, the pSer/Thr-Pro motifs in proteins exist...

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Hlavní autoři: Ryo, Akihide, Liou, Yih-Cherng, Wulf, Gerburg, Nakamura, Masafumi, Lee, Sam W., Lu, Kun Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC133940/
https://ncbi.nlm.nih.gov/pubmed/12101225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.15.5281-5295.2002
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